Substrate: Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )
Seq-ID: P03372 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-13786   BRCA1_HUMAN
MINT-50646   STA5A_HUMAN
MINT-50709   M3K1_HUMAN
MINT-5222241   NCOA1_HUMAN
MINT-6169667   EGFR_HUMAN
MINT-6614126   SMCA4_HUMAN
MINT-6614301   CHD3_HUMAN
MINT-6614361   MTA1_HUMAN
MINT-6614421   MTA2_HUMAN
MINT-6761899   PTN1_HUMAN
MINT-6761906   PTN6_HUMAN
MINT-7013584   PA1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
beta-catenin binding,
nitric-oxide synthase regulator activity,
estrogen response element binding,
steroid binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
estrogen receptor activity		 chromatin remodeling complex response to estradiol stimulus,
transcription, DNA-dependent,
regulation of transcription, DNA-dependent,
positive regulation of retinoic acid receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 46 ERPLGEVYLDSSKPAVYNYPE - 20043841
LTP
0.14
 - Oest_recep
0.37
 --
S 47 RPLGEVYLDSSKPAVYNYPEG - 20043841
LTP
0.91
 - Oest_recep
0.38
 --
Y 52 VYLDSSKPAVYNYPEGAAYEF - 20101225
LTP
0.00
 SHC1 SH2 Oest_recep
0.31
 --
S 102 NGLGGFPPLNSVSPSPLMLLH GSK-3_beta 16076840
LTP
0.85
 MOD_GSK3_1
 - Oest_recep
0.46
 --
S 102 NGLGGFPPLNSVSPSPLMLLH - 18984578
LTP
0.85
 MOD_GSK3_1
 - Oest_recep
0.46
 --
S 104 LGGFPPLNSVSPSPLMLLHPP - 8308015
LTP
0.61
 MOD_GSK3_1
 - Oest_recep
0.48
 --
S 104 LGGFPPLNSVSPSPLMLLHPP CDK_group 10949034
LTP
0.61
 MOD_GSK3_1
 - Oest_recep
0.48
 --
S 104 LGGFPPLNSVSPSPLMLLHPP GSK-3_beta 10949034
LTP
0.61
 MOD_GSK3_1
 - Oest_recep
0.48
 --
S 104 LGGFPPLNSVSPSPLMLLHPP GSK-3_beta 16076840
LTP
0.61
 MOD_GSK3_1
 - Oest_recep
0.48
 --
S 104 LGGFPPLNSVSPSPLMLLHPP CDK_group 10428798
LTP
0.61
 MOD_GSK3_1
 - Oest_recep
0.48
 --
S 104 LGGFPPLNSVSPSPLMLLHPP - 18984578
LTP
0.61
 MOD_GSK3_1
 - Oest_recep
0.48
 --
S 104 LGGFPPLNSVSPSPLMLLHPP - 16741565
LTP
0.61
 MOD_GSK3_1
 - Oest_recep
0.48
 --
S 104 LGGFPPLNSVSPSPLMLLHPP - 20043841
LTP
0.61
 MOD_GSK3_1
 - Oest_recep
0.48
 --
S 106 GFPPLNSVSPSPLMLLHPPPQ - 8308015
LTP
0.96
 MOD_GSK3_1
 - Oest_recep
0.52
 --
S 106 GFPPLNSVSPSPLMLLHPPPQ - 10949034
LTP
0.96
 MOD_GSK3_1
 - Oest_recep
0.52
 --
S 106 GFPPLNSVSPSPLMLLHPPPQ GSK-3_beta 16076840
LTP
0.96
 MOD_GSK3_1
 - Oest_recep
0.52
 --
S 106 GFPPLNSVSPSPLMLLHPPPQ CDK_group 10428798
LTP
0.96
 MOD_GSK3_1
 - Oest_recep
0.52
 --
S 106 GFPPLNSVSPSPLMLLHPPPQ - 18984578
LTP
0.96
 MOD_GSK3_1
 - Oest_recep
0.52
 --
S 106 GFPPLNSVSPSPLMLLHPPPQ - 16741565
LTP
0.96
 MOD_GSK3_1
 - Oest_recep
0.52
 --
S 106 GFPPLNSVSPSPLMLLHPPPQ - 20043841
LTP
0.96
 MOD_GSK3_1
 - Oest_recep
0.52
 --
S 118 LMLLHPPPQLSPFLQPHGQQV RSK_group 7838153
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV MAPK_group 12093745
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV - 9528769
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV CDK7 10949034
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV GSK-3_beta 16076840
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV - 15528270
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV CDK7 15461668
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV MAPK1 15059947
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV MAPK_group 12118371
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV CDK7 12118371
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV MAPK3 7491495
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV - 18984578
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV - 16741565
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV - 20043841
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 154 AGPPAFYRPNSDNRRQGGRER - 18984578
LTP
0.29
 - Oest_recep
0.72
 --
S 167 RRQGGRERLASTNDKGSMAME RSK_group 7838153
LTP
0.28
 MOD_PKB_1
 - Oest_recep
0.75
 --
S 167 RRQGGRERLASTNDKGSMAME - 9528769
LTP
0.28
 MOD_PKB_1
 - Oest_recep
0.75
 --
S 167 RRQGGRERLASTNDKGSMAME RSK_group 11432835
LTP
0.28
 MOD_PKB_1
 - Oest_recep
0.75
 --
S 167 RRQGGRERLASTNDKGSMAME PKB_beta 11139588
LTP
0.28
 MOD_PKB_1
 - Oest_recep
0.75
 --
S 167 RRQGGRERLASTNDKGSMAME - 18984578
LTP
0.28
 MOD_PKB_1
 - Oest_recep
0.75
 --
S 167 RRQGGRERLASTNDKGSMAME - 16741565
LTP
0.28
 MOD_PKB_1
 - Oest_recep
0.75
 --
S 212 CEGCKAFFKRSIQGHNDYMCP - 18984578
LTP
1.00
 - ZnF_C4
0.19
 1HCQ 1.64%
Y 219 FKRSIQGHNDYMCPATNQCTI - 20101225
LTP
1.00
 - ZnF_C4
0.33
 1HCQ 22.71%
S 236 QCTIDKNRRKSCQACRLRKCY PKA_group 9891036
LTP
1.00
 MOD_PKA_1
 - ZnF_C4
0.22
 1HCQ 73.77%
S 236 QCTIDKNRRKSCQACRLRKCY - 18984578
LTP
1.00
 MOD_PKA_1
 - ZnF_C4
0.22
 1HCQ 73.77%
S 236 QCTIDKNRRKSCQACRLRKCY - 16741565
LTP
1.00
 MOD_PKA_1
 - ZnF_C4
0.22
 1HCQ 73.77%
S 282 DDGEGRGEVGSAGDMRAANLW - 20043841
LTP
0.19
 - -
0.51
 --
S 294 GDMRAANLWPSPLMIKRSKKN - 18984578
LTP
0.16
 - -
0.34
 --
S 294 GDMRAANLWPSPLMIKRSKKN - 20043841
LTP
0.16
 - -
0.34
 --
S 305 PLMIKRSKKNSLALSLTADQM PAK1 12374744
LTP
0.93
 - -
0.31
 2QA8 64.75%
S 305 PLMIKRSKKNSLALSLTADQM - 15193262
LTP
0.93
 - -
0.31
 2QA8 64.75%
S 305 PLMIKRSKKNSLALSLTADQM - 16741565
LTP
0.93
 - -
0.31
 2QA8 64.75%
S 305 PLMIKRSKKNSLALSLTADQM - 16452229
LTP
0.93
 - -
0.31
 2QA8 64.75%
S 305 PLMIKRSKKNSLALSLTADQM - 17627277
LTP
0.93
 - -
0.31
 2QA8 64.75%
T 311 SKKNSLALSLTADQMVSALLD MAPK_group 12138194
LTP
0.27
 - -
0.28
 2IOG 52.05%
T 311 SKKNSLALSLTADQMVSALLD MAPK14 12138194
LTP
0.27
 - -
0.28
 2IOG 52.05%
T 311 SKKNSLALSLTADQMVSALLD - 16741565
LTP
0.27
 - -
0.28
 2IOG 52.05%
Y 537 SMKCKNVVPLYDLLLEMLDAH Lck 7539106
LTP
0.96
 Src SH2 Hormone_recep
0.06
 2IOG 27.07%
Y 537 SMKCKNVVPLYDLLLEMLDAH SRC 7539106
LTP
0.96
 Src SH2 Hormone_recep
0.06
 2IOG 27.07%
Y 537 SMKCKNVVPLYDLLLEMLDAH - 16741565
LTP
0.96
 Src SH2 Hormone_recep
0.06
 2IOG 27.07%
S 554 LDAHRLHAPTSRGGASVEETD - 18984578
LTP
0.10
 - -
0.61
 --
S 559 LHAPTSRGGASVEETDQSHLA - 18984578
LTP
0.57
 - -
0.67
 --
S 559 LHAPTSRGGASVEETDQSHLA - 20043841
LTP
0.57
 - -
0.67
 --

Substrate: Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )
Seq-ID: P19785 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
steroid binding,
transcription factor binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
steroid hormone receptor activity		 cytoplasm,
nucleus		 positive regulation of fibroblast proliferation,
prostate epithelial cord elongation,
transcription,
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis,
antral ovarian follicle growth,
male gonad development,
cell growth,
vagina development,
mammary gland branching involved in pregnancy,
negative regulation of mitosis,
epithelial cell development,
epithelial cell proliferation involved in mammary gland duct elongation,
regulation of branching involved in prostate gland morphogenesis,
regulation of transcription, DNA-dependent,
uterus development,
androgen metabolic process,
mammary gland alveolus development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 122 LMLLHPPPQLSPFLHPHGQQV - 14647453
LTP
1.00
 - Oest_recep
0.46
 - medium
S 156 RDTGPPAFYRSNSDNRRQNGR - 8541227
LTP
0.90
 - Oest_recep
0.70
 - medium
S 158 TGPPAFYRSNSDNRRQNGRER - 8541227
LTP
0.30
 - Oest_recep
0.72
 - medium
S 171 RRQNGRERLSSSNEKGNMIME - 14647453
LTP
0.26
 - Oest_recep
0.74
 - medium
S 298 GDMRAANLWPSPLVIKHTKKN - 8541227
LTP
0.10
 - -
0.39
 - medium

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